University of Jyväskylä

Dissertation: 6.4.2018 Modeling of intracellular transport in realistic cell geometries (Aho)

Start date: Apr 06, 2018 12:00 PM

End date: Apr 06, 2018 03:00 PM

Location: Ylistönrinne, FYS1

Photo by Vesa Aho
M.Sc. Vesa Aho defends his doctoral dissertation in Physics "Modeling of intracellular transport in realistic cell geometries". Opponent Professor Matthias Weiss (University of Bayreuth, Germany) and Custos Docent Maija Vihinen-Ranta (University of Jyväskylä). The doctoral dissertation is held in English.

The transport of molecules inside cells is a complex process, the characterization of which is important to gain full understanding of cellular processes. Understanding of intracellular transport is also important for medical applications, for example when analyzing transport of medicine inside cells. The intracellular environment is very complex, and at least the most crucial parts of this complexity must be accounted for to solve transport problems in cells. In this thesis the results of studies in modeling intracellular transport are presented. The aim of the work was to model intracellular transport of proteins and viral capsids in realistic cell environments. To this end, microscopic methods were used to image cellular structures, which were then digitally reconstructed and used as an environment for modeling particle transport in numerical simulations.

The dissertation is published in the series Department of Physics, University of Jyväskylä, Report number 4. ISSN 0075-465X, ISBN 978-951-39-7385-8.

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