Research interests in our research group

We study the molecular mechanisms of the developmental toxicity of polycyclic aromatic hydrocarbons (PAHs) in fish. PAHs are ubiquitous contaminants in the environment. They originate mainly from combustion of organic material and petroleum products. Many PAHs cause developmental defects in vertebrates. Fish are the most sensitive class, and cardiovascular tissue seems to be the most sensitive target tissue. The risk assessment of PAHs is currently oversimplified, and it underestimated the risk to developing fish. Our aim is to reveal mechanisms of toxicity by which different PAHs and their binary mixtures cause cardiovascular toxicity in developing fish. The results can be utilized in the environmental risk assessment of PAHs, making it more reliable.

Selected publications

Vehniäinen, Eeva-Riikka, Katharina Bremer, Jason A. Scott, Sini Junttila, Asta Laiho, Attila Gyenesei, Peter V. Hodson, and Aimo OJ Oikari. "Retene causes multifunctional transcriptomic changes in the heart of rainbow trout (Oncorhynchus mykiss) embryos." Environmental toxicology and pharmacology 41 (2016): 95-102. https://doi.org/10.1016/j.etap.2015.11.015