Systemic and intracrine estrogen and microRNAs mediate the risk of metabolic dysfunction in middle-aged women - EsmiRs study


   Aging and menopause, which result from the loss of ovarian estradiol production, are associated with fat accumulation and an increase in metabolic dysfunction risk factors. Furthermore, aging and menopause lead to reduction of skeletal muscle mass and performance capacity. The EsmiRs-study investigates the biological mechanisms behind these menopause-related adverse health changes. The study uses molecular biology, physiology, endocrinology, and genome-wide sequencing methods in combination with sport and health science research methods. One of our lines of research investigates the role of estradiol in inter-tissue microRNA signaling, and whether this relates to the increased risk of metabolic diseases during aging. We also study the cellular mechanisms behind skeletal muscle aging, such as skeletal muscle apoptosis and its regulation, as well as skeletal muscle steroidogenesis.

The EsmiRs-study is largely based on the ERMA-study and complemented with new data collection. In addition, we use in vivo and in vitro design. The study has been conducted at the Gerontology Research Center of the University of Jyväskylä.

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