BrainTalks

Mild cognitive impairment (MCI) is a condition between normal aging and dementia with an elevated risk of disease progression. Current Alzheimer’s disease biomarkers either correlate poorly with progression or detect pathology only at later stages of the disease. Recently, magnetoencephalography (MEG) has emerged as a promising noninvasive measure of synaptic dysfunction in memory disorders. Using two paradigms that probe semantic relatedness and speech-in-noise processing, I will show how semantic processing shifts with healthy aging and how reduced decodability of semantic information from MEG data may serve as an early marker of cognitive impairment in MCI.