Multi-scale muscle remodeling in cerebral palsy: active–passive interplay across scales

Muscle remodeling in cerebral palsy is a multi-scale phenomenon. Changes at the protein and sarcomere level propagate to muscle composition, stiffness, and ultimately muscle–tendon function and movement. The goal of this seminar is to integrate experimental and modeling perspectives across scales, from sarcomeres to whole muscle–tendon function, and to discuss how this knowledge can advance both mechanistic understanding and clinical practice.
This event is related to this research project

Event information

Event date
-
Event type
Public lectures, seminars and round tables
Event language
English
Event accessibility
Event space is accessible for all
Event address

Mattilaniemi 2
Jyväskylä 40700
Finland

Event organizer
Faculty of Sport and Health Sciences
Event payment
Free of charge
Event location category
Mattilanniemi
AgAlfa Ag B122.1 Alfa

Program

10:00 – 10:30 (25min+5 min discussion) - Francesco Cenni. What do we know about multi-scale muscle remodelling in cerebral palsy? Overview of my current project

10:30 – 11:00 (25min+5min discussion) - Walter Herzog. Structural and functional changes of skeletal muscles in children with cerebral palsy

11:00 – 11:30 (25min+5min discussion) - Kaat Desloovere. Macro- and microscopic muscle size and compositional parameters of skeletal muscles in children with spastic cerebral palsy

11:30-12:00 Open discussion guided by moderators.

Possible questions: what are the main unknown across scales in CP muscle remodeling? What are the current experimental and conceptual limitations? Do we have the right technology to address these questions?

12:00 – 13:30 - Lunch break

13:30 – 14:00 (25min+5min discussion) – Taija Finni. The role of Achilles tendon in muscle adaptation

14:00 – 14:30 (25min+5min discussion) - Juha Pekka Kulmala. What do we know about the contribution of passive components to function in cerebral palsy?

14:30 – 15:00 (20min+10min discussion) – Hans Kainz. Personalizing musculoskeletal properties in neuromuscular diseases

15:00 – 16:00 Coffee break, concluding remarks and follow ups

17:30 – 21:30 Social program – dinner cruise

Registration / Enrollment

If you are interested in joining this seminar, please briefly describe your interest and write to francesco.l.cenni@jyu.fi

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Related content

Overview of the project, starting from the clinical problem and progressing through multiscale analyses to the mapping and modeling of muscle properties
Project

Mapping and modeling skeletal muscle properties in children and young adults with cerebral palsy (MaMo)

To map and model multiscale muscle-tendon properties to understand how structural adaptations influence active and passive force generation in cerebral palsy