Virus-nucleus interactions

Our research seeks to advance the knowledge of nuclear dynamics and interactions by employing a new interdisciplinary approach combining biology and biophysics with state-of-the-art techniques of imaging, advanced image analysis, and biophysical modeling.

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Visit our group webpage link (https://mvr-lab.org/)

Overview

Core fields of research

Basic natural phenomena and mathematical thinking

Research areas

Nanobiology

Nanoscience Center

Health and well-being (NSC)

Sustainable society

Faculty

Faculty of Mathematics and Science

Department

Department of Biological and Environmental Science

Research group description

We wish to understand the mechanisms of nuclear import, intranuclear mobility and nuclear export of parvoviruses and herpesviruses in order to understand the biological processes of infection. Our findings will help to understand some critical factors in viral infection which up to now to a large extent have gone unrecognized.

Current

Members

Research group

Group leaders

Maija Vihinen-Ranta

Research Director

Members

Academy Research Fellow

Visa Ruokolainen

Senior Lecturer

Satu Hakanen

Postdoctoral Researcher

External members

Dr. Axel Ekman

Subcontractor in Horizon 2020 CoCID project

Publications

Publication

2023

Iterative immunostaining combined with expansion microscopy and image processing reveals nanoscopic network organization of nuclear lamina

Molecular Biology of the Cell.

Mäntylä, Elina

Montonen, Toni

Azzari, Lucio

Mattola, Salla

Hannula, Markus

Vihinen-Ranta, Maija

Hyttinen, Jari

Vippola, Minnamari

Foi, Alessandro

Nymark, Soile

Ihalainen, Teemu O.

Publication

2023

Mitochondrial Reorganization in Herpesvirus-Infected Cells

Microscopy Society of America and Microanalysis Society Annual Meeting. Microscopy and Microanalysis.

Leclerc, S.

Kunnas, K.

Ekman, A.

Pereiro, E.

Fahy, K.

Larabell, C.

Aho, V.

Weinhardt, V.

Vihinen-Ranta, M.

Publication

2022

G2/M checkpoint regulation and apoptosis facilitate the nuclear egress of parvoviral capsids

Frontiers in cell and developmental biology.

Mattola, Salla

Mäntylä, Elina

Aho, Vesa

Salminen, Sami

Leclerc, Simon

Oittinen, Mikko

Salokas, Kari

Järvensivu, Jani

Hakanen, Satu

Ihalainen, Teemu O.

Viiri, Keijo

Vihinen-Ranta, Maija

Publication

2022

Gap junctions and connexin hemichannels both contribute to the electrical properties of retinal pigment epithelium

Journal of General Physiology.

Fadjukov, Julia

Wienbar, Sophia

Hakanen, Satu

Aho, Vesa

Vihinen-Ranta, Maija

Ihalainen, Teemu O.

Schwartz, Gregory W.

Nymark, Soile

Publication

2022

Nuclear entry and egress of parvoviruses

Molecular Microbiology.

Mattola, Salla

Aho, Vesa

Bustamante‐Jaramillo, Luisa F.

Pizzioli, Edoardo

Kann, Michael

Vihinen‐Ranta, Maija

Publication

2022

Parvovirus nonstructural protein 2 interacts with chromatin-regulating cellular proteins

PLoS Pathogens.

Mattola, Salla

Salokas, Kari

Aho, Vesa

Mäntylä, Elina

Salminen, Sami

Hakanen, Satu

Niskanen, Einari A.

Svirskaite, Julija

Ihalainen, Teemu O.

Airenne, Kari J.

Kaikkonen-Määttä, Minna

Parrish, Colin R.

Varjosalo, Markku

Vihinen-Ranta, Maija

Publication

2022

Soft X-ray Tomography Reveals HSV-1-Induced Remodeling of Human B Cells

Viruses.

Chen, Jian-Hua

Vanslembrouck, Bieke

Ekman, Axel

Aho, Vesa

Larabell, Carolyn A.

Le Gros, Mark A.

Vihinen-Ranta, Maija

Weinhardt, Venera

Publication

2021

Compact Cell Imaging Device (CoCID) provides insights into the cellular origins of viral infections

JPhys Photonics.

Fahy, Kenneth

Weinhardt, Venera

Vihinen-Ranta, Maija

Fletcher, Nicola

Skoko, Dunja

Pereiro, Eva

Gastaminza, Pablo

Bartenschlager, Ralf

Scholz, Dimitri

Ekman, Axel

McEnroe, Tony

Publication

2021

Concepts to Reveal Parvovirus–Nucleus Interactions

Viruses.

Mattola, Salla

Hakanen, Satu

Salminen, Sami

Aho, Vesa

Mäntylä, Elina

Ihalainen, Teemu O.

Kann, Michael

Vihinen-Ranta, Maija

Publication

2021

Functional roles of the membrane-associated AAV protein MAAP

Scientific Reports.

Galibert, Lionel

Hyvönen, Amira

Eriksson, Reetta A. E.

Mattola, Salla

Aho, Vesa

Salminen, Sami

Albers, Justin D.

Peltola, Sanna K.

Weman, Saija

Nieminen, Tiina

Ylä-Herttuala, Seppo

Lesch, Hanna P.

Vihinen-Ranta, Maija

Airenne, Kari J.

Publication

2021

Infection-induced chromatin modifications facilitate translocation of herpes simplex virus capsids to the inner nuclear membrane

PLoS Pathogens.

Aho, Vesa

Salminen, Sami

Mattola, Salla

Gupta, Alka

Flomm, Felix

Sodeik, Beate

Bosse, Jens B.

Vihinen-Ranta, Maija

Publication

2021

Persistence of Human Bocavirus 1 in Tonsillar Germinal Centers and Antibody-Dependent Enhancement of Infection

mBio.

Xu, Man

Perdomo, Maria Fernanda

Mattola, Salla

Pyöriä, Lari

Toppinen, Mari

Qiu, Jianming

Vihinen-Ranta, Maija

Hedman, Klaus

Nokso-Koivisto, Johanna

Aaltonen, Leena-Maija

Söderlund-Venermo, Maria