Virus-nucleus interactions

Our research seeks to advance the knowledge of nuclear dynamics and interactions by employing a new interdisciplinary approach combining biology and biophysics with state-of-the-art techniques of imaging, advanced image analysis, and biophysical modeling.

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Visit our group webpage link (https://mvr-lab.org/)

Overview

Core fields of research

Basic natural phenomena and mathematical thinking

Research areas

Nanobiology

Nanoscience Center

Health and well-being (NSC)

Sustainable society

Faculty

Faculty of Mathematics and Science

Department

Department of Biological and Environmental Science

Research group description

We wish to understand the mechanisms of nuclear import, intranuclear mobility and nuclear export of parvoviruses and herpesviruses in order to understand the biological processes of infection. Our findings will help to understand some critical factors in viral infection which up to now to a large extent have gone unrecognized.

Current

Members

Research group

Group leaders

Maija Vihinen-Ranta

Research Director

Members

Academy Research Fellow

External members

Dr. Axel Ekman

Subcontractor in Horizon 2020 CoCID project

Publications

Publication

2014

Epigenetic Upregulation of Endogenous VEGF-A Reduces Myocardial Infarct Size in Mice

Plos One.

Turunen, Mikko P.

Husso, Tiia

Musthafa, Haja

Laidinen, Svetlana

Dragneva, Galina

Laham-Karam, Nihay

Honkanen, Sanna

Paakinaho, Anne

Laakkonen, Johanna P.

Gao, Erhe

Vihinen-Ranta, Maija

Liimatainen, Timo

Ylä-Herttuala, Seppo

Publication

2014

Subcellular localization of bacteriophage PRD1 proteins in Escherichia coli

Virus Research.

Karttunen, Jenni

Mäntynen, Sari

Ihalainen, Teemu

Lehtivuori, Heli

Tkachenko, Nikolai

Vihinen-Ranta, Maija

Ihalainen, Janne

Bamford, Jaana

Oksanen, Hanna

Publication

2013

Mutations in DNA Binding and Transactivation Domains Affect the Dynamics of Parvovirus NS1 Protein

Journal of Virology.

Niskanen, Einari

Kalliolinna, Olli

Ihalainen, Teemu

Häkkinen, Milla

Vihinen-Ranta, Maija

Publication

2012

Distribution and dynamics of transcription-associated proteins during parvovirus infection.

Journal Of Virology.

Ihalainen, Teemu

Willman, Sami

Niskanen, Einari

Paloheimo, Outi

Smolander, Hanna

Laurila, Juha

Kaikkonen, Minna

Vihinen-Ranta, Maija

Publication

2011

Coxsackievirus B3-Induced Cellular Protrusions: Structural Characteristics and Functional Competence

Journal of Virology.

Paloheimo, Outi

Ihalainen, Teemu

Tauriainen, Sisko

Välilehto, Outi

Kirjavainen, Sanna

Niskanen, Einari

Laakkonen, Johanna

Hyöty, Heikki

Vihinen-Ranta, Maija

Publication

2011

Protein diffusion in mammalian cell cytoplasm

PLoS ONE.

Kühn, Thomas

Ihalainen, Teemu

Hyväluoma, Jari

Dross, Nicolas

Willman, Sami

Langowski, Jörg

Vihinen-Ranta, Maija

Timonen, Jussi

Publication

2010

Culture Medium Induced Vimentin Reorganization Associates With Enhanced Baculovirus-mediated Gene Delivery

Journal of Biotechnology.

Mähönen, Anssi

Makkonen, Elina

Laakkonen, Johanna

Ihalainen, Teemu

Kukkonen, Sari

Kaikkonen, Minna U.

Vihinen-Ranta, Maija

Ylä-Herttuala, Seppo

Airenne, Kari

Publication

2010

Effect of ATP binding and hydrolysis on dynamics of canine parvovirus NS1

Journal of Virology.

Niskanen, Einari

Ihalainen, Teemu

Häkkinen, Milla

Kalliolinna, Ollli

Vihinen-Ranta, Maija

Publication

2010

Morphological characterization of baculovirus Autographa californica multiple nucleopolyhedrovirus.

Virus Research.

Ihalainen, Teemu

Laakkonen, Johanna

Paloheimo, Outi

Ylä-Herttuala, Seppo

Airenne, Kari

Vihinen-Ranta, Maija

Publication

2009

Clathrin-independent entry of baculovirus triggers uptake of E. coli in non-phagocytic human cells

Plos One.

Laakkonen, Johanna

Mäkelä, Anna

Kakkonen, Elina

Turkki, Paula

Kukkonen, Sari

Peränen, Johan

YläHerttuala, Seppo

Airenne, Kari

Oker-Blom, Christian

Vihinen-Ranta, Maija

Marjomäki, Varpu

Publication

2009

Parvovirus induced alterations in nuclear architecture and dynamics

PLoS ONE.

Ihalainen, Teemu

Niskanen, Einari

Jylhävä, J.

Paloheimo, O.

Dross, N.

Smolander, H.

Langowski, J.

Timonen, Jussi

Vihinen-Ranta, Maija

Publication

2008

Baculovirus-mediated immediate-early gene expression and nuclear reorganization in human cells

Cellular Microbiology.

Laakkonen, Johanna

Kaikkonen, Minna

Ronkainen, Paula

Ihalainen, Teemu

Niskanen, Einari

Häkkinen, Maija

Kulomaa, Markku

Ylä-Herttuala, Seppo

Airenne, Kari

Vihinen-Ranta, Maija