Genetic and biological drivers of physical activity and exercise participation (GEDROPA)

Genetics is one of the most important factors explaining physical activity. Twin studies suggest that genes account for around 30-60% of the observed behaviour. The basis for the genetic regulation of physical activity behaviour is strong, going back to human evolution and the selection of traits that have contributed to survival in a world of limited resources. Due to methodological shortcomings, it has not been possible to study earlier the variation between individuals in this phenomenon and to explain why some are more active than others. Genetics may also explain why some people develop physical fitness more easily than others, or experience more pleasure from physical activity.

It is important to study the influence of genetics on the choice of a physically active lifestyle, as there is a risk that health-promoting activities will only activate those who are naturally active or who derive exceptional benefits from physical activity. This may even lead to an increase in health inequalities in the population. Only recent methodological and data infrastructure breakthroughs have enabled the study of genome-wide variation in individuals and physical activity at the population level. We use previously untapped large biobank datasets and their accelerometer-measured and self-reported physical activity data. We also make use of longitudinal lifestyle intervention studies in Finns of different ages.