Virus-nucleus interactions

Our research seeks to advance the knowledge of nuclear dynamics and interactions by employing a new interdisciplinary approach combining biology and biophysics with state-of-the-art techniques of imaging, advanced image analysis, and biophysical modeling.

Want to find out more?
Visit our group webpage link below (https://mvr-lab.org/)

Table of contents

Research group type
Research group
Core fields of research
Basic natural phenomena and mathematical thinking
Research areas
Nanobiology
Nanoscience Center
Health and well-being (NSC)
Sustainable society
Faculty
Faculty of Mathematics and Science
Department
Department of Biological and Environmental Science

Research group description

We wish to understand the mechanisms of nuclear import, intranuclear mobility and nuclear export of parvoviruses and herpesviruses in order to understand the biological processes of infection. Our findings will help to understand some critical factors in viral infection which up to now to a large extent have gone unrecognized.

Publications

Publication
2024

Dynamin independent endocytosis is an alternative cell entry mechanism for multiple animal viruses

PLoS Pathogens.
Ojha, Ravi
Jiang, Anmin
Mäntylä, Elina
Quirin, Tania
Modhira, Naphak
Witte, Robert
Gaudin, Arnaud
De Zanetti, Lisa
Gormal, Rachel Sarah
Vihinen-Ranta, Maija
Mercer, Jason
Suomalainen, Maarit
Greber, Urs F.
Yamauchi, Yohei
Lozach, Pierre-Yves
Helenius, Ari
Vapalahti, Olli
Young, Paul
Watterson, Daniel
Meunier, Frédéric A.
Joensuu, Merja
Balistreri, Giuseppe
Publication
2024

Herpesvirus-Induced Manipulation of the Nucleolus

Microscopy and Microanalysis.
Leclerc, Simon
Kapishnikov, Sergey
Ruokolainen, Visa
Huusko, Inka
Mattola, Salla
Rogers, David
O´Connor, Stephen
Aho, Vesa
Fahy, Kenneth
Vihinen-Ranta, Maija
Publication
2024

Progression of herpesvirus infection remodels mitochondrial organization and metabolism

PLoS pathogens.
Leclerc, Simon
Gupta, Alka
Ruokolainen, Visa
Chen, Jian-Hua
Kunnas, Kari
Ekman, Axel A.
Niskanen, Henri
Belevich, Ilya
Vihinen, Helena
Turkki, Paula
Perez-Berna, Ana J.
Kapishnikov, Sergey
Mäntylä, Elina
Harkiolaki, Maria
Dufour, Eric
Hytönen, Vesa
Pereiro, Eva
McEnroe, Tony
Fahy, Kenneth
Kaikkonen, Minna U.
Jokitalo, Eija
Larabell, Carolyn A.
Weinhardt, Venera
Mattola, Salla
Aho, Vesa
Vihinen-Ranta, Maija
Publication
2023

Creation of ordered 3D tubes out of DNA origami lattices

Nanoscale.
Parikka, Johannes M.
Järvinen, Heini
Sokołowska, Karolina
Ruokolainen, Visa
Markešević, Nemanja
Natarajan, Ashwin K.
Vihinen-Ranta, Maija
Kuzyk, Anton
Tapio, Kosti
Toppari, J. Jussi
Publication
2023

Mitochondrial Reorganization in Herpesvirus-Infected Cells

Microscopy Society of America and Microanalysis Society Annual Meeting. Microscopy and Microanalysis.
Leclerc, S.
Kunnas, K.
Ekman, A.
Pereiro, E.
Fahy, K.
Larabell, C.
Aho, V.
Weinhardt, V.
Vihinen-Ranta, M.

Research group

Group leaders

Maija Vihinen-Ranta

Maija Vihinen-Ranta

Research Director

Members

Vesa Aho

Postdoctoral Researcher

Alka Gupta

Senior Researcher
Moona Huttunen

Moona Huttunen

Senior Researcher

Salla Mattola

Academy Research Fellow

Visa Ruokolainen

Postdoctoral Researcher

Satu Hakanen

Doctoral Researcher

External members

Dr. Axel Ekman

Subcontractor in Horizon 2020 CoCID project

Related news

mitochondria-Cryo-soft X-ray tomography 3D
Science news
7.5.2024

Progression of herpesvirus infection remodels mitochondrial organization and metabolism

Recent research shows that herpesvirus infection modifies the structure and normal function of the mitochondria in the host cell.