Virus-nucleus interactions

Our research seeks to advance the knowledge of nuclear dynamics and interactions by employing a new interdisciplinary approach combining biology and biophysics with state-of-the-art techniques of imaging, advanced image analysis, and biophysical modeling.

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Visit our group webpage link (https://mvr-lab.org/)

Overview

Core fields of research

Basic natural phenomena and mathematical thinking

Research areas

Nanobiology

Nanoscience Center

Health and well-being (NSC)

Sustainable society

Faculty

Faculty of Mathematics and Science

Department

Department of Biological and Environmental Science

Research group description

We wish to understand the mechanisms of nuclear import, intranuclear mobility and nuclear export of parvoviruses and herpesviruses in order to understand the biological processes of infection. Our findings will help to understand some critical factors in viral infection which up to now to a large extent have gone unrecognized.

Current

Members

Research group

Group leaders

Maija Vihinen-Ranta

Research Director

Members

Academy Research Fellow

External members

Dr. Axel Ekman

Subcontractor in Horizon 2020 CoCID project

Publications

Publication

2002

The VP1 N-terminal sequence of canine parvovirus affects nuclear transport of capsids and efficient cell infection

Journal of virology.

Vihinen-Ranta, Maija

Weichert, W.

Wang, D.

Parrish, C.R.

Publication

2000

Cytoplasmic trafficking of the canine parvovirus capsid and its role in infection and nuclear transport

Journal of Virology.

Vihinen-Ranta, Maija

Parrish, Colin

Publication

1999

A neutralizing antibody against human DNA polymerase epsilon inhibits cellular but not SV40 DNA replication

Nucleic Acids Research.

Pospiech, Helmut

Kursula, Inari

Abdel-Aziz, Waleed

Malkas, Linda

Uitto, Lahja

Kastelli, Maaret

Vihinen-Ranta, Maija

Eskelinen, Sinikka

Syväoja, Juhani E.

Publication

1998

Intracellular route of canine parvovirus entry

Journal of Virology.

Vihinen-Ranta, Maija

Kalela, Anne

Mäkinen, Päivi

Kakkola, Laura

Marjomäki, Varpu

Vuento, Matti

Publication

1997

Characterization of a nuclear localization signal of canine parvovirus capsid proteins

European Journal of Biochemistry.

Vihinen-Ranta, Maija

Kakkola, Laura

Kalela, Anne

Vuento, Matti

Publication

1996

Detection of canine parvovirus antigens with antibodies to synthetic peptides

Archives of Virology.

Vihinen-Ranta, Maija

Lindfors, Erja

Heiska, Leena

Veijalainen, Pirjo

Vuento, Matti

Publication

1994

A microcomputer simulation of peptide sequencing

Biochemical Education.

Vihinen-Ranta, Maija

Vuento, Matti

Publication

1993

Characterization of antigenic epitopes of potato virus Y

Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology.

Vuento, Matti

Paananen, Kalevi

Vihinen-Ranta, Maija

Kurppa, Antti

Publication

1993

Characterization of antigenic epitopes of the coat protein of potato virus X by systematic Immunochemical analysis of synthetic peptides

Acta Chemica Scandinavica.

Vuento, Matti

Vihinen-Ranta, Maija

Paananen, Kalevi

Kurppa, Antti